NFATc4 RegulatesSox9Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation
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منابع مشابه
NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation
Acinar transdifferentiation toward a duct-like phenotype constitutes the defining response of acinar cells to external stress signals and is considered to be the initial step in pancreatic carcinogenesis. Despite the requirement for oncogenic Kras in pancreatic cancer (PDAC) development, oncogenic Kras is not sufficient to drive pancreatic carcinogenesis beyond the level of premalignancy. Inste...
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The roles of inflammatory macrophages in pancreatic tissue and the development of pancreatic cancer have not been well characterized. Recently it was shown that inflammatory macrophages, besides their function in clearing dead cells, also initiate pancreatic acinar cell metaplasia to duct-like progenitor cells. While in pancreatitis this is a reversible process, in context of an oncogenic stimu...
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The high level of interest in the pancreatic acinar cell over the past 25 years is a reflection of the fact that this system is a paradigm for the study of protein synthesis, sorting, and secretion. Moreover, pancreatic inflammation is a serious clinical problem that may relate to a disorder in the basic organization of this cell. The discussions by Pandol, Steer, Grendell, and myself are close...
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ژورنال
عنوان ژورنال: Stem Cells International
سال: 2016
ISSN: 1687-966X,1687-9678
DOI: 10.1155/2016/5272498